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340B teams are facing ever-rising expectations and workloads. Programs must juggle core operational responsibilities while continuously adapting to evolving policies and regulatory changes (especially as we’ve experienced over the past several months).
In conversations with 340B leaders across the country, we consistently hear the same theme: teams are looking to AI and automation to reduce manual burden and enable their programs to scale sustainably.
Yet the paradox remains. With so much to do and so little time to do it, how can covered entities realistically make room to implement new solutions?
The Answer
Automation solutions, including CompassRx, have demonstrated the ability to reduce manual effort by as much as 80 percent for certain workflows (such as eliminating phone calls and automating compliance checks). Still, many teams hesitate because of the perceived upfront time and effort required to get these tools in place.
While no solution can create more hours in the day, covered entities can be deliberate about choosing partners that minimize implementation burden, accelerate time to value, and reduce the risk of wasted effort.
What to Look for in a Partner
- Low- or No-Integration Solutions
Deep IT integrations are often delayed by competing health system priorities, making EHR or pharmacy system access difficult and time-consuming. Some solutions, like CompassRx, are designed to work with standard EHR reports and data exports that IT teams can typically provide in hours rather than months. - Fast Time to Value
How long does it take to begin to see value and see a return on your “time investment?” It’s important to evaluate not only how long implementation takes, but how quickly the solution begins delivering meaningful results (e.g. team time saved, increased 340B capture, increased pharmacy traffic).
How to De-Risk Your Time Investment
- Performance Guarantees
To ensure your team’s time and resources are well spent, we strongly recommend contractual performance guarantees. These protections help mitigate the risk of underperforming or misaligned solutions. Whatever you deem is the most important metric you’re solving for (e.g. % of claims audited, $’s of opportunity identified), you can negotiate to make sure it’s guaranteed. - True AI Expertise
Like many covered entities, here at CompassRx we also use other automation and AI vendors to make our team’s life easier. What we’ve learned is to exclusively work with AI-native companies. AI-native solutions are those that were originally built with AI in mind versus solutions where AI has been added retroactively onto older, pre-AI technology. For us, such AI-native solutions have consistently delivered more value to solving our day-to-day problems compared to those that try to incorporate AI to an older technology not designed for it.
How CompassRx Gives Time Back Without Needing a Major Upfront Investment
At CompassRx, we offer solutions with all of these criteria in mind. Our AI-native platform requires no API integrations to get started, delivers value from day one, and is backed by contractual performance guarantees designed to protect your covered entity.
If you’re looking to give your team meaningful time back while supporting the growth and sustainability of your 340B pharmacy program, we’d love to connect. Reach out to us at hello@compassrx.com.

Alice Cheng is chief operating officer of CompassRx. She can be reached at alice@compassrx.com.


