The 340B landscape is shifting faster than most programs can keep up. Court rulings are challenging HRSA’s authority. The rebate model remains uncertain. Manufacturers continue to tighten restrictions. And IRA-driven claim issues are creating new gaps in visibility, reimbursement, and program integrity. At the same time, expectations haven’t changed. Covered entities are still being asked to maintain compliance, protect savings, and operate efficiently in an environment that is anything but stable. So, what does this actually mean for your program? In this session, we’ll cut through the noise and focus on what matters. We’ll unpack the latest legal and policy developments, including child site implications, rebate model uncertainty, manufacturer behavior, and IRA/MFP claim disruption, and translate them into what you should be paying attention to right now. More importantly, we’ll connect these shifts to operational impact. Where programs are most exposed. Where opportunities still exist. And what actions leading organizations are taking to stay ahead, maintain control, and avoid costly missteps. This isn’t about reacting to headlines. It’s about understanding how the 340B program is evolving and what that means for programs trying to maintain clarity, control, and performance.